Texas Cowboys Against Cancer was inspired by the spirit and example of Johnnie Neely. When her brother, Joe Powell, was diagnosed with throat cancer, she organized a rodeo benefit in his name to help defray the cost of treatment. With the help of family and friends, the benefit was a great success. Then, when Johnnie was diagnosed with breast cancer, Joe returned the gesture with a benefit in her name.

Following Johnnie's benefit, the family decided they would like to continue the tradition of helping those who face the hardship, expense, and emotional burden of cancer. In July, 2009, Texas Cowboys Against Cancer was formed.

Johnnie Neely lost her battle with cancer in October of 2010. Her family and friends were present when she went home to her Savior, Jesus Christ. Texas Cowboys Against Cancer is dedicated to continuing her example of generosity and compassion.